Practical Medicinal Chemistry - III

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Publisher: Prime Publishing House
ISBN: 9789395596275
Year: 2022
Pages: 64

“Practical Medicinal Chemistry–III” is a comprehensive and student-oriented laboratory manual designed to provide hands-on understanding of essential concepts in medicinal chemistry. The book presents practical experiments in a clear and systematic manner, enabling learners to bridge the gap between theoretical knowledge and laboratory application.

The manual covers the synthesis of important medicinal compounds and intermediates, offering step-by-step procedures that help in understanding reaction mechanisms and practical techniques. It also includes detailed methods for the assay of various drugs, emphasizing accuracy, analytical skills, and standard pharmaceutical practices.

Special focus has been given to modern approaches such as microwave-assisted synthesis, introducing learners to advanced and efficient techniques used in contemporary laboratories. In addition, the book incorporates the use of computational tools, enabling students to draw chemical structures and reactions, and to evaluate physicochemical properties such as logP, molecular weight, and hydrogen bonding parameters.

With its structured format and emphasis on practical skills, this book serves as a valuable resource for developing laboratory competence, analytical thinking, and a deeper understanding of medicinal chemistry experiments.

I. Some Medicinal Drug and Intermediates Synthesis
1. To prepare sulphanilamide from acetanilide.
2. To prepare 7-hydroxy-4-methyl coumarin from resorcinol.
3. To prepare of Chlorobutanol from acetone.
4. To prepare Triphenyl imidazole from Benzil.
5. To prepare tolbutamide from p-toluene sulfonamide.
6. To prepare hexamine from formaldehyde.

II. Assay of Some Medicinal Drugs
7. To perform assay of Isoniazide tablet.
8. To perform assay of Chloroquine.
9. To perform assay of Metronidazole.
10. To perform assay of Dapsone.
11. To perform assay of Chlorpheniramine Maleate IP.
12. To perform assay of Crystalline Benzyl penicillin.

III. Microwave Assisted Synthesis
13. Synthesis of Phenytoin by using microwave system.
14. Synthesis of tetrahydro pyrimidine by using microwave system.
15. Synthesis of Tetrahydrocarbazole by using microwave system.
16. Synthesis of aspirin from salicylic acid by using microwave system.
17. Synthesis of Paracetamol from aminophenol by using microwave system.

IV. Drawing structures and reactions using chem draw

A book as per the latest syllabus given by Pharmacy Council of India (PCI) New Delhi for B.Pharm students of all Indian Universities

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