Practical Medicinal Chemistry - I
Practical Medicinal Chemistry - I

Practical Medicinal Chemistry - I

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Publisher: Prime Publishing House
ISBN: 9789395596268
Year: 2022
Pages: 70

“Practical Medicinal Chemistry–I” is a well-structured and student-oriented laboratory manual designed to provide a clear understanding of fundamental experimental techniques in medicinal chemistry. The book focuses on developing practical skills through systematic and easy-to-follow procedures, enabling learners to connect theoretical concepts with laboratory applications.

The manual includes the synthesis of important medicinal compounds and intermediates such as benzimidazole, benzocaine, phenytoin, barbiturates, and phenothiazine, helping students understand reaction mechanisms and synthetic approaches. It also covers the assay of commonly used drugs, emphasizing accuracy, analytical methods, and standard pharmaceutical practices.

In addition, the book introduces the determination of partition coefficients of drugs, providing insight into physicochemical properties that influence drug absorption and distribution. The inclusion of computational tools and ChemDraw basics further enhances learning by familiarizing students with modern techniques used in medicinal chemistry.

With its clear presentation and focus on hands-on learning, this book serves as a valuable resource for building laboratory competence, analytical skills, and a strong foundation in practical medicinal chemistry.

I. Safety in Laboratory

II. Some Medicinal Drugs and Intermediates Synthesis
1. To prepare Benzimidazole from o-phenylenediamine.
2. To prepare Antipyrine (1,3 pyrazole derivative) from ethylacetoacetate and phenyl hydrazine.
3. To prepare Benzocaine from p-nitro toluene.
4. To prepare 5, 5-Diphenyl Hydantoin (Phenytoin) Sodium from benzophenone.
5. To prepare barbituric acid from urea.
6. To prepare benzotriazole from o-phenylenediamine.
7. To prepare 4-Benzylidene-2-phenyloxazol-5-one from Benzoylglycine.
8. To prepare phenothiazine from Diphenylamine.
9. To prepare 2,3 diphenyl quinoxaline from benzil.

III. Assay of some Medicinal Drugs
10. To perform assay of Chlorpromazine Hydrochloride.
11. To perform assay of Atropine.
12. To perform assay of phenobarbitone.
13. To perform assay of Ibuprofen.
14. To perform assay of aspirin I.P.
15. To perform assay of furosemide.

IV. Determination of Partition coefficient of some drugs
16. To determine the partition coefficient of salicylic acid between n-octanol and distilled water (Flask method).
17. To determine 1-octanol/water partition coefficients of ciprofloxacin by shake-flask method.
18. To determine 1-octanol/water partition coefficients of Sulfamethazine, sulfamethoxazole by shake-flask method.

V. ChemDraw

VI. Computational tools in the medicinal chemistry

A book as per the latest syllabus given by Pharmacy Council of India (PCI) New Delhi for B.Pharm students of all Indian Universities

तुम्हाला हे देखील वाचायला आवडेल

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